ANTIHERPETIC ACTION OF CERIUM SALTS IN VITRO

Compounds based on cerium are highly promising objects in biotechnology regarding their high biological activities such as antiviral, antibacterial, antifungal, neuro- and radioprotective action, antioxidant activity. On basis is possible to develop compositions capable of activating the systems cellular humoral immune defence use them for prevention therapy viral diseases, which makes it achievable development potential antiherpetic agents. Despite success application biotechnological fields, mechanism action requires detailed research. The work aimed verify vitro anti-HSV-1/2 activity trivalent tetravalent salts (1 mM – 0.01 nM) according preventive therapeutic regimen. Methods: virological, cytological, statistical. Results. regime was noneffective. In regime, salt (NH4)2Ce(NO3)6 forms antiviral resistance range investigated concentrations, while CeCl3·7Н2О a non-linear, sinusoidal-like concentration-dependent response cells. Conclusions. Cerium (III IV) can cause formation state model system MA-104 - HSV-1/2 during previous 24 h contact with test (IV) provides 50% inhibition cytopathic at concentration 1 μM. It assumed that shown may be due effect interferon